PCR & SEQUENCING SIMULATION

▸ Loading template DNA & forward/reverse primer pair…
▸ Mixing thermostable Taq polymerase + dNTPs
▸ Calibrating thermal cycle 95° / 55° / 72°C
▸ Mounting the 4-colour Sanger sequencing reader
▸ Ready — Online. ✅
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⌂ Cells

Simulation room PCR & gene sequencing

Polymerase Chain Reaction · Sequencing
Online
×2 per cycle · 2ⁿ
Block temp & amplification
🔬 PCR thermal cycle
white needle = target temperature
Current step
Block temperature
Cycle
Target copies (~2ⁿ)
Annealing temp
Base read
Notes
PCR repeats 3 steps: denaturation 95°C strand separation → annealing ~55°C → extension 72°C (Taq). Each cycle the target copy number ×2 → after n cycles ≈ 2ⁿ copies. Only the stretch between the 2 primers is selectively amplified.
Adjust ANNEALING TEMP & CYCLE COUNT on the right · pick a scenario (Run 2ⁿ · Sequencing · Gel · qPCR) · click “Cycle diagram” to see the 3 steps
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Target DNA copies per cycle (log) 2ⁿ amplification