Cell Signaling · Cell & Genetics

CELL SIGNALING SIMULATION

▸ Building the phospholipid bilayer & nucleus…

▸ Inserting GPCR · RTK · intracellular receptors

▸ Wiring intracellular cascades: G-protein · cAMP · MAPK

▸ Releasing signaling molecules (ligands)

▸ Calibrating amplification & feedback

▸ Ready — Online. ✅

Signal status

📡 Signaling pathway

input · cascade · amplification · response

Ligand bound—

Cascade lit—

Amplification—

Response—

Scenario—

Viewing—

Note

A signal runs in 3 phases: a ligand binds the receptor (reception) → a protein/second-messenger chain amplifies and relays it inward → reaching the nucleus to switch on genes or give a fast response. A small signal → a large response thanks to cascade amplification; loss of feedback → stuck "on" (cancer).

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Drag "Ligand concentration" & pick a "Scenario" (GPCR → cAMP · RTK → MAPK · steroid → nucleus · amplification · apoptosis · cancer) · click a component or concept for details

Your browser has not enabled canvas — cannot render the simulation.

Input · cascade · response over time ligand boundcascaderesponse